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The researchers utilized direct reprogramming (transdifferentiation) to convert aged dermal fibroblasts from elderly human donors (aged 61-68) directly into induced cortical neurons (iNs)

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Mancini M, Rengo F, Lingetti M, et al

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Heavy Metal Exposure Humans are exposed to various heavy metals from food, water, and the environment (1, 2): Mercury from seafood, high-fructose corn syrup, rice, and beauty products Arsenic from soil, crops, water, fertilizer, and tobacco Cadmium from batteries, plastic stabilizers, vegetables, chocolate, and cigarettes Lead from soil, house paint, smoking, and batteries Antimony from food, water, coal, and medicine Tungsten from industrial sources, water, and food Heavy metals are distributed to almost all tissues